The Open PHACTS Discovery Platform was developed to reduce barriers to drug discovery in industry, academia and for small businesses. It contains various data sources, integrated and linked together so that the relationships between compounds, targets, pathways, diseases, tissues and publications can be easily found. Data sources include ChEBI, ChEMBL, ChemSpider, ConceptWiki, DisGeNET, DrugBank, Gene Ontology, neXtProt, UniProt and WikiPathways.

Open PHACTS (or “OPS” for short) was funded for 5 years by IMI, and is now maintained by the independent Open PHACTS Foundation which continues collaboration with the eScience Lab, BioExcel and Excelerate.

eScience Lab contributions

eScience Lab contributed multiple products that together form the the Open PHACTS Platform:

Mark D. Wilkinson, Michel Dumontier, IJsbrand Jan Aalbersberg, Gabrielle Appleton, Myles Axton, Arie Baak, Niklas Blomberg, Jan-Willem Boiten, Luiz Bonino da Silva Santos, Philip E. Bourne, Jildau Bouwman, Anthony J. Brookes, Tim Clark, Mercè Crosas, Ingrid Dillo, Olivier Dumon, Scott Edmunds, Chris T. Evelo, Richard Finkers, Alejandra Gonzalez-Beltran, Alasdair J.G. Gray, Paul Groth, Carole Goble, Jeffrey S. Grethe, Jaap Heringa, Peter A.C ’t Hoen, Rob Hooft, Tobias Kuhn, Ruben Kok, Joost Kok, Scott J. Lusher, Maryann E. Martone, Albert Mons, Abel L. Packer, Bengt Persson, Philippe Rocca-Serra, Marco Roos, Rene van Schaik, Susanna-Assunta Sansone, Erik Schultes, Thierry Sengstag, Ted Slater, George Strawn, Morris A. Swertz, Mark Thompson, Johan van der Lei, Erik van Mulligen, Jan Velterop, Andra Waagmeester, Peter Wittenburg, Katherine Wolstencroft, Jun Zhao & Barend Mons (2016) The FAIR Guiding Principles for scientific data management and stewardship Nature Scientific Data 3, 2016 doi:10.1038/sdata.2016.18

Paul Groth, Antonis Loizou, Alasdair J.G. Gray, Carole Goble, Lee Harland, Steve Pettifer (2014): API-centric Linked Data integration: The Open PHACTS Discovery Platform case study Web Semantics: Science, Services and Agents on the World Wide Web doi:10.1016/j.websem.2014.03.003 [researchgate]

Joseline Ratnam , Barbara Zdrazil, Daniela Digles, Emiliano Cuadrado-Rodriguez, Jean-Marc Neefs, Hannah Tipney, Ronald Siebes, Andra Waagmeester, Glyn Bradley, Chau Han Chau, Lars Richter, Jose Brea, Chris T. Evelo, Edgar Jacoby, Stefan Senger, Maria Isabel Loza, Gerhard F. Ecker, Christine Chichester (2014): The Application of the Open Pharmacological Concepts Triple Store (Open PHACTS) to Support Drug Discovery Research PLoS ONE 9(12): e115460. doi:10.1371/journal.pone.0115460

Alasdair J. G. Gray, Paul Groth, Antonis Loizou, Sune Askjaer, Christian Brenninkmeijer, Kees Burger, Christine Chichester, Chris T. Evelo, Carole Goble, Lee Harland, Steve Pettifer, Mark Thompson, Andra Waagmeester, Antony J. Williams (2014): Applying linked data approaches to pharmacology: Architectural decisions and implementation. Semantic Web 5(3), 1–13. [pdf] [journal article] [doi:10.3233/SW-2012-0088

Carole Goble, Alasdair J G Gray, Eleftherios Tatakis (2014): Help me describe my data: A demonstration of the Open PHACTS VoID Editor. ISWC-P&D 2014: Proceedings of the ISWC 2014 Posters & Demonstrations Track, CEUR-WS.org online http://ceur-ws.org/Vol-1272/paper_33.pdf

Christian Brenninkmeijer, Chris Evelo, Carole Goble, Alasdair J G Gray, Paul Groth, Steve Pettifer, Robert Stevens, Antony J Williams, Egon L Willighagen (2013): Scientific Lenses: An Approach to Dynamically Vary the Relationships between Datasets. Intelligent Systems for Molecular Biology and European Conference on Computational Biology (ISMB/ECCB 2013), Berlin, Germany, July 2013. [pdf]

Paolo Ciccarese, Stian Soiland-Reyes, Khalid Belhajjame, Alasdair JG Gray, Carole Goble, Tim Clark (2013): PAV ontology: provenance, authoring and versioning. Journal of Biomedical Semantics 4:1, 37. doi:10.1186/2041-1480-4-37

Christian Y A Brenninkmeijer, Ian Dunlop, Carole Goble, Alasdair J G Gray, Steve Pettifer, Robert Stevens (2013): Computing Identity Co-Reference Across Drug Discovery Datasets. Proceedings of the 6th International Workshop on Semantic Web Applications and Tools for Life Sciences (SWAT4LS); CEUR-WS.org; 2013. http://ceur-ws.org/Vol-1114/Session4_Brenninkmeijer.pdf

Kamal Azzaoui, Edgar Jacoby, Stefan Senger, Emiliano Cuadrado Rodríguez3, Mabel Loza, Barbara Zdrazil, Marta Pinto, Antony J. Williams, Victor de la Torre, Jordi Mestres, Manuel Pastor, Olivier Taboureau, Matthias Rarey, Christine Chichester, Steve Pettifer, Niklas Blomberg, Lee Harland, Bryn Williams-Jones, Gerhard F. Ecker (2013): Scientific competency questions as the basis for semantically enriched open pharmacological space development Drug Discovery Today 18 (17-18) pp 843–852.

Antony J. Williams, Lee Harland, Paul Groth, Stephen Pettifer, Christine Chichester, Egon L. Willighagen, Chris T. Evelo, Niklas Blomberg, Gerhard Ecker, Carole Goble, Barend Mons (2012):
Open PHACTS: semantic interoperability for drug discovery, Drug Discovery Today 17(21-22) pp 1188 - 1198. doi:10.1016/j.drudis.2012.05.016

Lee Harland (2012): Open PHACTS: A Semantic Knowledge Infrastructure for Public and Commercial Drug Discovery Research 18th International Conference, EKAW 2012, Galway City, Ireland, October 8-12, 2012. Proceedings doi:10.1007/978-3-642-33876-2_1 [preprint]